Sonic Hedgehog Signaling in Basal Cell Nevus Syndrome
نویسندگان
چکیده
منابع مشابه
Sonic hedgehog signaling in Basal cell nevus syndrome.
The hedgehog (Hh) signaling pathway is considered to be a major signal transduction pathway during embryonic development, but it usually shuts down after birth. Aberrant Sonic hedgehog (Shh) activation during adulthood leads to neoplastic growth. Basal cell carcinoma (BCC) of the skin is driven by this pathway. Here, we summarize information related to the pathogenesis of this neoplasm, discuss...
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The development of basal cell carcinoma, the commonest human cancer in fair skinned populations, is clearly associated with constitutive activation of sonic hedgehog signaling. Insight into the genesis of BCC came from the identification of germline mutations of the tumor suppressor gene, PATCHED, a key regulatory component of hedgehog signaling in the nevoid basal cell carcinoma syndrome. Anal...
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To cite: Nair PP, Khilari M, Peddawad D, et al. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/bcr-2013200545 DESCRIPTION A 20-year-old woman presented with history of headache for 1 year. The headaches were mild to moderate in intensity, bilateral and non-throbbing, with no symptoms suggestive of raised intracranial pressure. The patient had hyperpigmented skin lesi...
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Mutations in the tumor suppressor gene PATCHED (PTC) are found in human patients with the basal cell nevus syndrome, a disease causing developmental defects and tumors, including basal cell carcinomas. Gene regulatory relationships defined in the fruit fly Drosophila suggest that overproduction of Sonic hedgehog (SHH), the ligand for PTC, will mimic loss of ptc function. It is shown here that t...
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The Author Replies: Although medical practitioners may possess the sophistication to distinguish among complementary, integrative, and alternative therapies, the average patient is unfortunately not as health-literate. Time and again, and nowhere more than in the field of oncology, the patients who turn to alternative therapies are those who eschew conventional treatment and feel that alternati...
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ژورنال
عنوان ژورنال: Cancer Research
سال: 2014
ISSN: 0008-5472,1538-7445
DOI: 10.1158/0008-5472.can-14-1666